Dermatology
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Post-Exposure Prophylaxis (PEP) refers to the preventive medical treatment administered after potential exposure to a pathogen, such as HIV, hepatitis B, or rabies, to reduce the risk of infection. It involves taking antiretroviral drugs or vaccines within a specific timeframe to halt disease progression.
PEP can be broadly classified into:
HIV PEP – A 28-day course of antiretroviral therapy initiated within 72 hours of exposure.
Hepatitis B PEP – Includes hepatitis B vaccine and immunoglobulin for non-immune individuals exposed to the virus.
PEP is crucial for preventing infections after occupational exposures (e.g., needlestick injuries in healthcare settings), non-occupational exposures (e.g., unprotected sexual contact, needle-sharing), and animal bites.
PEP is not 100% effective, with its success dependent on early initiation (preferably within hours of exposure), adherence to the full treatment course, and individual immune response. It does not provide long-term immunity, making pre-exposure prophylaxis (PrEP) and vaccination vital for at-risk individuals.
A dermatologist should be consulted if skin-related reactions such as severe rashes, allergic reactions, or medication-induced dermatitis occur during PEP treatment. Additionally, if exposure involves skin injuries, bites, or lesions, dermatological evaluation can help assess infection risks and appropriate care.
